Evaluate potential differences in microbiome response to omeprazole between brachycephalic dogs and non-brachycephalic dogs.
Purpose of study
Omeprazole is a commonly used antacid in veterinary medicine. This study is designed to assess if omeprazole changes normal microbiomes found in the esophagus and feces of healthy dogs. Changes in microbiome could worsen some conditions in dogs with illnesses affecting the esophagus. These changes in the esophagus could put these dogs at risk of aspiration pneumonia or other disease complications. This study includes brachycephalic dogs, which are pre-disposed to upper gastrointestinal and esophageal disorders, as well as non-brachycephalic dogs.
Benefits
Your dog will receive no direct benefit from this study, but their involvement could help change the use of this medication and others like it in veterinary medicine. The information gained in this study could decrease the risk of aspiration pneumonia in brachycephalic dogs with esophageal disease. For your pet’s participation you will receive a $25 amazon gift card and a goody bag. All diagnostic results will become a permanent part of your dog’s medical record.
Enrollment requirements
- Eligible dogs must be healthy, 2- 7 years of age, over 15 lbs, and not have been on any antacid medications, antibiotics or probiotics within the last 3 months.
- Dogs must be cooperative for physical exam and having their mouths touched.
- Dogs must be willing to take oral medication.
Treatment methods
Once enrolled, your dog will have 3 separate visits to the WSU Veterinary Teaching Hospital. These visits will include a complete physical examination, a complete blood count, biochemistry panel, urinalysis, fecal exam, as well as collection of secretions from the esophagus and fecal samples for microbiome analysis.
Owner responsibilities
- This study will require the owner to bring their dog to the WSU VTH for appointments 3 times during a 58-day period.
- Owners must agree to administer medications as directed and report any problems with medications or with their dogs. In addition, owners must keep a log when the medication is given and if there are any missed doses.
Contact Information
For more information, please contact Jennifer Heusser, Clinical Studies Coordinator, jpmarcus3@wsu.edu, 509-592-3669.